PHYSICIANS BOOKLET

TUMOR AND CANCER STEM CELL ACTIVITY MARKER

The medical revolution to tame

# 01 HISTORY

# 02 WHAT IS INTRACELLULAR PROGASTRIN?

# 03 WHAT IS hPG80 (THE CIRCULATING PROGASTRIN)?

# 04 WHAT INFORMATION GIVES US hPG80?

# 05 THE WNT PATH: ITS CONTINUOUS ACTIVATION IS ESSENTIAL TO CANCER

# 06 TRACK WNT / hPG80 - RUNNING?

# 07 WHY DETECT OR DOSAGE hPG80?

# 08 HOW TO DETECT AND DOSAGE hPG80?

• A quick reminder of what a test is

• WHAT TESTS CAN DETECT OR DOSAGE hPG80?

• WHAT DOES DxPG80 MEAN?

• HOW TO DETECT / DOSER hPG80?

• HOW TO USE DxPG80 TESTS?

# 09 HOW TO INTERPRET THE RESULTS OF hPG80 ANALYSIS

# 10 COMMUNICATE WITH THE PATIENT

# 11 THE PROGASTRIN CANCER CONTROL ASSOCIATION

PATIENTS LEAFLET

# 1. THE INTEREST OF DETECTING CANCER IN EARLY STAGES

# 2. EVOLUTION OF CANCER

# 3. WHERE DOES THIS NEW BIOMARKER COME FROM?

# 4. HOW DOES THE TEST GO?

# 5. YOU ARE POSITIVE FOR A hPG80 DETECTION TEST.

# 6. CANCER: WHO IS YOUR PARTNER IN THIS FIGHT?

# 7. WHAT IS A TUMOR MARKER?

# 8. NO TEST IS 100% RELIABLE

# 9. DETECT A SUSCEPTIBILITY TO CANCER

# 10. MONITORING THE EFFECTIVENESS OF A THERAPY

# 11. DETECTING RECURRENCE EARLY

French

English

PATHOLOGY SHEETS and CLINICAL CASE STUDY

hPG80 for Recurrence Monitoring

FR_v02

hPG80 for Assessing Individual Response to Treatment
/ Minimal Residual Disease

FR_v01

hPG80 for Treatment Resistance Control

FR_v01

hPG 80 for Cancer Screening before symptoms

FR_v01

HCC / hPG80 for the Detection and Monitoring of Hepatocellular Carcinoma

FR_v01

RCC / hPG80 for the Management of Renal Carcinoma

FR_v01

WHITE PAPER

hPG80 (CIRCULATING PROGASTRIN) AND ITS LINK TO CANCER:

FROM THE DISCOVERY OF PROGASTRIN TO THE TUMOR REVERSION

INTRODUCTION. WHAT IS A TUMOR?

# 01 WHAT IS PROGASTRIN?

# 02 WHERE IS PROGASTRIN EXPRESSED IN PHYSIOLOGICAL CONDITIONS?

# 03 THE LINK BETWEEN PROGASTRIN AND CANCER: HOW HAS IT BEEN SHOWN?

# 04 PROGASTRIN IS PRESENT IN THE PLASMA OF PATIENTS WITH COLORECTAL CANCER

# 05 PROGASTRIN AND ITS FUNCTIONS IN CANCER CELLS

. PROGASTRIN AND TUMOR CELL PROLIFERATION

. PROGASTRIN IS A PROMOTER OF INTESTINAL TUMORIGENESIS

. PROGASTRIN IS ESSENTIAL FOR THE SURVIVAL OF CANCER STEM CELLS

# 06 BY WHAT MECHANISMS DOES PROGASTRIN CONTROL THE FORMATION OF A TUMOR?

. PROGASTRIN REDUCES APOPTOSIS
. PROGASTRIN REGULATES ADHERENT AND TIGHT JUNCTIONS

. PROGASTRIN IS A PRO-ANGIOGENIC FACTOR
. PROGASTRIN AND HYPOXIA

# 07 WHAT IS THE RECEPTOR FOR PROGASTRIN? WHAT'S CERTAIN: THE RECEPTOR EXISTS

# 08 PROGASTRIN AND ONCOGENIC SIGNALING PATHWAYS

# 09 PROGASTRIN AND WNT PATH

# 10 HOWEVER, AND IT IS OF CAPITAL IMPORTANCE:

REDUCING PROGASTRIN PRODUCTION
CAUSES WNT PATHWAY INACTIVATION
AND THE TUMORIGENESIS PROCESS REVERSION

# 11 PROGASTRIN AS A TARGET TO FIGHT CANCER

REFERENCES